TS10C: PROTEIN AGGREGATION AND FORMULATION OPTIMIZATION
Thursday, AUGUST 15 and Friday, August 16
DAY ONE: 1:30 – 5:00 PM | DAY TWO: 8:30 AM – 3:30 PM
Thomas Laue, PhD, Professor Emeritus, Biochemistry, and Molecular Biology; Director, Biomolecular Interaction Technologies Center (BITC), University of New Hampshire
Kevin Mattison, PhD, Principal Scientist, Malvern Pananalytical, Inc.
Matthew Brown, PhD, Applications Manager, Bioscience, Malvern PANalytical, Inc.
Molecular interactions are central to protein discovery and development and formulation development. This training seminar allows a fundamental, but very practical, understanding of protein interactions, solution behavior, aggregate formation and its
application to formulation optimization. Building on a review of central energy concepts, the framework allows a deeper understanding of protein structural stability, interactions with small molecules, surfaces, itself, other proteins, and other macromolecules.
A deeper insight is afforded into the binding, solubility, viscosity, and detection and characterization of protein aggregates
- Current Challenges
- Understanding Protein Interactions
- Protein folding and solution stability
- Protein interactions, Cooperative interactions
- Prediction of protein solution behavior
- Protein Aggregation and Viscosity
- Proteins at high concentrations
- Describing protein aggregates
- Understanding the impact on formulation stability
- Detection and Characterization of Protein Aggregates
- Tools for detection and characterization of protein interactions
- Tools for the prediction of aggregation
- What are the key analytical challenges in characterizing protein aggregates?
- Analytical tools for prediction and quantification of protein aggregates
- Impact of Aggregates on Formulation Development
- Formulation optimization
- Particle interactions and Case studies
WHO SHOULD ATTEND:
This seminar is useful for senior scientists, protein chemists, structural chemists, technicians and post-docs who work with proteins. It will benefit anyone involved in the development or use of binding assays, anyone characterizing protein structure
and stability, protein formulations and anyone focused on protein biological functions.
Thomas Laue, PhD, Professor
Emeritus, Biochemistry and Molecular Biology; Director, Biomolecular Interaction Technologies Center (BITC), University of New Hampshire
Tom Laue is the emeritus Carpenter Professor of Molecular, Cellular and Biomedical Sciences, and professor of Material Sciences at the University of New Hampshire. He is the Director Emeritus of the Center to Advance Molecular Interaction Science and
the Biomolecular Interaction Technologies Center. He received his bachelor’s degree in Natural Sciences from the Johns Hopkins University in 1971 and his PhD in Biophysics and Biochemistry from the University of Connecticut in 1981. His post-doctoral
studies were conducted at the University of Oklahoma. Between 1969 and 1975, he worked as a technician in the deep space program of NASA. He joined the University of New Hampshire in 1984 as an Assistant Professor, where he taught both undergraduate
and graduate courses in biochemistry and biophysics. His research focused on the development of instrumentation and methods for examining macromolecular interactions. These instruments provide unique insights into these interactions and resulted in
extensive collaborations with both academic and industrial labs. Tom has over 120 publications, serves on several editorial boards, and gives over one hundred lectures, seminars and workshops a year.
Kevin Mattison, PhD, Principal Scientist Bioanalytics, Malvern PANalytical
Dr. Mattison completed his doctorate in biological chemistry at Purdue University, where he studied the effects of polyelectrolyte additives on the stability and activity of transport proteins and enzymes. From there he joined Protein Solutions as the
Applications Development and Technical Support Manager and was instrumental in helping to drive the adoption of sub-micron light scattering techniques from esoteric technologies into mainstream laboratory tools. In 2002 Dr. Mattison joined Malvern
Instruments, where he served as Applications Manager, Product Manager, and Director of Customer Support, prior to assuming his current position as Principal Scientist – Bioanalytics in the Strategic Technology Development Group.
Matthew Brown PhD, Applications Manager, Bioscience, Malvern PANalytical
Matt Brown completed his PhD at the University of London and followed this with Postdoctoral Fellowships at Harvard Medical School, in Boston, USA. Prior to joining Malvern Panalytical, Matt worked in the biopharmaceutical sector, employing a range of
biophysical and biochemical methods to support bioprocess development and commercial manufacturing operations. Currently, Matt is the Bioscience Applications Manager for the US, specializing in the Biopharmaceutical sector.
Training Seminar Information
Each CHI Training Seminar offers 1.5 days of instruction with start and stop times for each day shown above and on the Event-at-a-Glance published in the onsite Program & Event Guide. Training Seminars will include morning and afternoon refreshment
breaks, as applicable, and lunch will be provided to all registered attendees on the full day of the class.
Each person registered specifically for the Training Seminar will be provided with a hard copy handbook for the seminar in which they are registered. A limited number of additional handbooks will be available for other delegates who wish to attend the
seminar, but after these have been distributed, no additional books will be available.
Though CHI encourages track hopping between conference programs, we ask that Training Seminars not be disturbed once they have begun. In the interest of maintaining the highest quality learning environment for Training Seminar attendees, and because seminars
are conducted differently than conference programming, we ask that attendees commit to attending the entire program, and not engage in track hopping, as to not disturb the hands-on style instruction being offered to the other participants.