This stream explores the latest CMC developments in ADCs, novel conjugates, oligonucleotides, and peptides, bringing together experts in bioprocessing, process chemistry, and analytical development to address shared challenges in complex molecule manufacturing. Part One provides a focused examination of CMC strategies for ADCs and next-generation conjugates, covering advances in conjugation chemistry, analytical control, formulation, safety, and scale-up. Part Two delves into oligonucleotide and peptide CMC, analysis, and manufacturing, highlighting synthetic, hybrid, and recombinant production platforms, solid- and liquid-phase synthesis, and formulation approaches. Part Three showcases innovations in recovery and purification for complex modalities, emphasizing emerging separation technologies, adaptable purification strategies, and methods to improve yield and product quality across diverse molecular formats.

Conferences Include:

Keynotes:

ADCs & CMC: The Complexity Remains—Do Next-Gen Conjugates Enable Streamlining?
Olivier J. Marcq, PhD, Senior Vice President, CMC, Tubulis GmbH

A Phase-Appropriate CMC Strategy for Synthetic Oligonucleotide Therapeutics
Bao Zhong Cai, PhD, Vice President, Oligonucleotide CMC, GondolaBio

Next-Generation Cation Exchange Chromatography Platform Process Development for Biologics Purification
Lihua Yang, PhD, Senior Principal Research Scientist, BioProcess Purification Development, AbbVie, Inc.