Cambridge Healthtech Institute’s 12th Annual

Optimizing Cell Line Development

Enhancing Expression

August 27-28, 2020

 

As the biopharma field becomes increasingly more complex, engineering cell lines remains a foundation for developing biologics. This foundation draws from emerging research and breakthrough strategies to achieve cell lines that accomplish project goals quickly and inexpensively. The Optimizing Cell Line Development conference brings together experts who will share how to best optimize codons, construct vectors, and select and engineer clones and host systems, while maintaining stability and consistency. The conference will also focus on automation, high-throughput, genomic research, glycoengineering, systems biology, and pathway delineation.

Preliminary Agenda

ADVANCING CELL LINE DEVELOPMENT

KEYNOTE PRESENTATION: At the R&D Interface: From Early Candidate Screen to Fast Manufacturing Cell Line Development and Optimization

Zorica Dragic, PhD, Principal Scientist & Lab Head, Cell Line Screening and Development, CLSD-NBC, Novartis Pharma AG

FEATURED PRESENTATION: Use of Next-Generation Sequencing in Cell Line Selection

Marieke Zhao, PhD, Associate Director, Cell Line Development, Mersana Therapeutics, Inc.

Advancing Biologics Development Programs with Legacy Cell Lines

Ren Liu, PhD, Associate Principal Scientist, Merck & Co., Inc.

HTP ANALYTICS AND AUTOMATION

Efficiency Gains by Integrating Automated and Manual Cell Line Development Workflows in One End-to-End Platform

Christoph Freiberg, PhD, Head, Product Management, Biologics, Genedata AG

Integrating High‐Throughput Analytics and Cell Imaging to Assess Early Productivity and Product Quality

Jishna Ganguly, MSc, Associate Research Scientist, Center of Excellence for Early Process Development, GlaxoSmithKline

DEVELOPING CHO-BASED CELL LINES

FEATURED PRESENTATION: HIF1 Signaling Pathway Implicated in Phenotypic Instability in a Chinese Hamster Ovary Production Cell Line

Lin Zhang, PhD, Research Fellow, Global Biologics, Pfizer Inc.

Modeling Chinese Hamster Ovary Cell Metabolism: A Systematic Look at Model Parameters and Risk of Overfitting

Matthew Schinn, PhD, Pfizer CHO Systems Biology Fellow, Center for CHO Systems Biology, University of California, San Diego (UCSD)

Process Development and Intensification for Antibody Production Using an Inducible CHO Cell Line

Olivier Henry, PhD, Professor, Chemical Engineering, École Polytechnique de Montréal

Differentiated N-Glycan Modifications of Anti-Aging Klotho Protein by CHO and HEK293 Have Therapeutic Implications for Managing Kidney Disease

Xiaotian Zhong, PhD, Senior Principal Scientist & Lab Head, BioMedicine Design, Pfizer Research Labs

HARNESSING OMICS TO SUPPORT CELL LINE DEVELOPMENT

Proteomic Analysis of CHO Cell Clones Prone to Proteolytic Clipping

Paula Meleady, PhD, Associate Director, National Institute for Cellular Biotechnology, Dublin City University

RNA-Seq: A Transcriptomics Approach to Understanding Genome Instability, Protein Production, and Metabolomics in CHO Cells to Lower the Costs of Medicine

Derrick Scott, PhD, Assistant Professor and Director, Bioinformatics, Delaware State University

Metabolomics Approach for Increasing CHO Cell Specific Productivity

Grace Yao, MS, Analytical CMC Manager, Bristol-Myers Squibb Co.

GLYCOSYLATION

Which Sugar Do You Want? Tailor-made Glycosylation of Therapeutic Proteins

Bjørn Voldborg, MS, Director, CHO Cell Line Development, The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark (TDU)

Monitoring, Regulation and Engineering of Cell Line Glycosylation

Manfred Wuhrer, PhD, Professor & Head, Proteomics & Glycomics, Center for Proteomics & Metabolomics, Leiden University




For more details on the conference, please contact:
Mary Ruberry
Senior Conference Director
Cambridge Healthtech Institute

Phone: (+1) 781-972-5421
Email: mruberry@healthtech.com

 

For partnering and sponsorship information, please contact:

Companies A-K
Sherry Johnson
Senior Manager, Business Development
Cambridge Healthtech Institute
Phone: (+1) 781-972-1359
Email: sjohnson@healthtech.com

Companies L-Z
Carolyn Cooke
Manager, Business Development
Cambridge Healthtech Institute
Phone: (+1) 781-972-5412
Email: ccooke@healthtech.com



Premier Sponsors:

Fujifilm-Diosynth-Logo

NanotemperTechnologies

Samsung_Biologics

UnchainedLabs
Vironova