Cell Line Development & Engineering
Engineering Cells That Deliver
8/11/2026 - August 12, 2026 ALL TIMES EDT
The Cell Line Development & Engineering conference brings together experts driving innovation in vector design, host-cell engineering, clone selection, and AI/ML-enabled cell-line development. The program covers advanced strategies for complex biologics including bispecifics, ADCs, viral vectors, DTE proteins, and RNA therapeutics. Attendees will explore cutting-edge approaches in genome editing, glycoengineering, process-fit cell lines, high-throughput clone selection, and predictive modeling for stability and productivity. This conference equips scientists with practical strategies to boost productivity, ensure stability, and accelerate translation from discovery to manufacturing.
Preliminary Agenda

Session Block

ENGINEERING HOST CELL LINES

KEYNOTE PRESENTATION: Cell Line Design Strategies for Improving Biotherapeutic Expression

Photo of Jack J Scarcelli, PhD, Senior Director, Head of Cell Line Development, Sanofi , Senior Director, Head of Cell Line Development , Sanofi
Jack J Scarcelli, PhD, Senior Director, Head of Cell Line Development, Sanofi , Senior Director, Head of Cell Line Development , Sanofi

While the advent of targeted and semi-targeted integration expression systems reduced risk of cell-line instability, it has simultaneously increased focus on expression-vector engineering to enhance titer and quality. This presentation examines expression improvements achieved through strategic vector design, including optimization of vector topologies and the inclusion and use of genetically-encoded reporter proteins. These approaches enable the development of a robust expression system capable of addressing increasingly complex portfolios.

What Does Secretion Look Like in a Single Cell?

Photo of Nathan E. Lewis, PhD, GRA Eminent Scholar and Professor, Center for Molecular Medicine Complex, Department of Biochemistry and Molecular Biology, University of Georgia , GRA Eminent Scholar & Professor , Biochemistry & Molecular Biology , University of Georgia
Nathan E. Lewis, PhD, GRA Eminent Scholar and Professor, Center for Molecular Medicine Complex, Department of Biochemistry and Molecular Biology, University of Georgia , GRA Eminent Scholar & Professor , Biochemistry & Molecular Biology , University of Georgia
Photo of Jean-Sebastien Maltais, PhD, Research Officer, Medical Devices, National Research Council Canada , Research Officer , Medical Devices , Natl Research Council Canada
Jean-Sebastien Maltais, PhD, Research Officer, Medical Devices, National Research Council Canada , Research Officer , Medical Devices , Natl Research Council Canada
Photo of Laura Zielewicz, PhD, Principal Scientist, Pfizer Inc. , Principal Scientist , Pfizer
Laura Zielewicz, PhD, Principal Scientist, Pfizer Inc. , Principal Scientist , Pfizer
Photo of Zhiwei Song, PhD, CSO, Nexa Biologics, Singapore , CSO , Nexa Biologics Pte. Ltd.
Zhiwei Song, PhD, CSO, Nexa Biologics, Singapore , CSO , Nexa Biologics Pte. Ltd.

Claire Pearce, PhD, Associate Director, Head of Mammalian Expression, Technologies Centre of Excellence (MET CoE), GSK , Associate Director, Head of Mammalian Expression , Technologies Centre of Excellence (MET CoE) , GSK

CLONE SELECTION, STABILITY, AND HIGH PRODUCING CELL LINES

KEYNOTE PRESENTATION: Adaptive Development: Aligning Cell-Line Optimization with Process Improvements for Enhanced Speed and Productivity

Photo of Christina S. Alves, PhD, Head, US Biologics Process Development, Takeda , Head, US Biologics Process Development , Takeda
Christina S. Alves, PhD, Head, US Biologics Process Development, Takeda , Head, US Biologics Process Development , Takeda

Screening Methods to Identify Clones with Favorable Meabolis Signatures

Hillary Miller, PhD, Principal Scientist, Cell Engineering and Analytical Sciences, Johnson & Johnson Innovative Medicine , Principal Scientist , Cell Engineering and Analytical Sciences , Johnson & Johnson Innovative Medicine

Photo of Susan Sharfstein, PhD, Professor of Nanoscale Science and Engineering, University at Albany , Professor , Nanoscale Science and Engineering , University at Albany
Susan Sharfstein, PhD, Professor of Nanoscale Science and Engineering, University at Albany , Professor , Nanoscale Science and Engineering , University at Albany
Photo of Jackson Leong, PhD, Senior Scientist, Cell Culture Process Development, Denali Therapeutics Inc. , Senior Scientist , Cell Culture Process Development , Denali Therapeutics Inc
Jackson Leong, PhD, Senior Scientist, Cell Culture Process Development, Denali Therapeutics Inc. , Senior Scientist , Cell Culture Process Development , Denali Therapeutics Inc

VECTOR DESIGN AND OPTIMIZATION

Plasmid Engineering for AAV Production and Increased Safety

Photo of Azadeh Sarfallah, PhD, Senior Scientist, Applied Viral Sciences, Genentech Inc. , Sr Scientist , Applied Viral Sciences , Genentech Inc
Azadeh Sarfallah, PhD, Senior Scientist, Applied Viral Sciences, Genentech Inc. , Sr Scientist , Applied Viral Sciences , Genentech Inc

Shuang Wei, PhD, Senior Scientist, Merck , Senior Scientist , Merck

Photo of Metewo Selase Enuameh, PhD, Associate Director, Vector Core Cell Line Development, REGENXBIO, Inc. , Associate Director , Vector Core Cell Line Development & Engineering , REGENXBIO Inc
Metewo Selase Enuameh, PhD, Associate Director, Vector Core Cell Line Development, REGENXBIO, Inc. , Associate Director , Vector Core Cell Line Development & Engineering , REGENXBIO Inc
Photo of Kavya Ganapathy, PhD, Postdoctoral Research Fellow, Genentech , Postdoctoral Fellow , Genentech
Kavya Ganapathy, PhD, Postdoctoral Research Fellow, Genentech , Postdoctoral Fellow , Genentech

For more details on the conference, please contact:

Mimi Langley

Executive Director, Conferences

Cambridge Healthtech Institute

Email: mlangley@healthtech.com

 

For sponsorship information, please contact:

 

Companies A-K

Phillip Zakim-Yacouby

Business Development Manager

Cambridge Healthtech Institute

Phone: (+1) 781-247-1815

Email: philzy@cambridgeinnovationinstitute.com

 

Companies L-Z

Aimee Croke

Senior Business Development Manager

Cambridge Healthtech Institute

Phone: (+1) 781-292-0777

Email: acroke@cambridgeinnovationinstitute.com