The Upstream Processing stream details innovations and best practices for the foundations of protein expression that support biological drugs, including cell line development, culturing cells, and issues surrounding bioproduction. New therapeutic modalities and the need for higher titer, higher producing cell lines, lower production cost, and accelerated development is giving rise to new tools and technologies for upstream process optimization and intensification. Examples include systems and synthetic biology, genetic engineering, digitalization, disposables, continuous/integrated processing, and real-time process monitoring and control.

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