New and unique molecules such as vaccines, AAV vectors, exosomes and recomb proteins coming down the pipeline are bringing a new set of challenges to the downstream process development team. The need to meet high upstream titers and the demand for lower cost are pushing companies to look toward disruptive innovations and creative strategies in purification and recovery. The Downstream Processing stream highlights technologies and strategies such as integrated/continuous processing, process intensification and optimization, advances in protein capture and recovery, control of product- and process-related impurities, as well as innovations in PAT, modeling and real-time processing.

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