Cambridge Healthtech Institute’s 19th Annual

Cell Line Development & Cell Culture Optimization

Improving Upstream Productivity and Biologics Quality

August 14-15, 2023

Advances in host cell engineering, better expression of cell lines and optimization of cell culture processes, have greatly accelerated upstream processing in the last decade, resulting in today's antibody production yield of 10g/L or more. Meanwhile, newer platforms and advanced technologies continue to present opportunities for companies to strive for higher productivity and quality. CHI’s Cell Line Development & Cell Culture Optimization conference invites scientists to share their latest experiences in cell line engineering, clone selection, expression of complex biologics, scaling-up and optimization of cell culture processes as well as the emerging trends in upstream processing including FD, AI/ML, digital twins, and modeling.

Coverage will include, but is not limited to:

New Platforms and Approaches
- Targeted integration
- Transposon-based cell line development
- Next-generation sequencing and single cell selection in cell line development
- Systems and synthetic biology
- Automation platform for cell line development
Host Cell Engineering and Clone Selection
- Crispr-cas9 for CHO host cell engineering
- Multiauxotrophic CHO cell line
- Vector engineering and synthetic promoters
- Clonality documentation and clone stability
Cell Banking and Freeze/Thaw Optimization
Stable Expression of Complex Biologics
- Optimization of glycosylation and product quality
Scaling-Up of Cell Culture Processes
Media and Supplementation Optimization
Emerging Trends in Cell Line Development and Upstream Processes
- Computation fluid dynamics (CFD)
- Application of predictive tools, modeling, machine learning, and digital twins
- Earlier prediction of cell line performance

The deadline for priority consideration is February 3, 2023.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

Opportunities for Participation: