This Upstream Bioprocessing stream spans the full spectrum of upstream innovation - from designing next-generation production cell lines to optimizing culture systems and exploring novel expression hosts, and provides a comprehensive look at the tools, strategies and technologies advancing today’s upstream development. The Cell Line Development & Engineering conference dives into host cell engineering strategies, vector optimization, clone selection and stability; while Cell Culture and Upstream Processing conference explores scaling up strategies, improving process robustness, optimizing mid-stream processes and implementing digital biomanufacturing. The pre-conference symposium on Novel & Alternative Expression Systems showcases the various alternative host systems – bacterial, yeast, insect, plant and cell-free and their adaptiveness to today’s biomanufacturing needs.

Conferences Include:

Keynotes:

Cell Line Design Strategies for Improving Biotherapeutic Expression
Jack J. Scarcelli, PhD, Senior Director, Head of Cell Line Development, Sanofi

Adaptive Development: Aligning Cell-Line Optimization with Process Improvements for Enhanced Speed and Productivity
Christina S. Alves, PhD, Head, US Biologics Process Development, Takeda

Converting Low-Seed Processes to Intensified Fed-Batch Processes through Smart Media Design and PAT Controls
Sarwat Khattak, PhD, Head of Cell Culture and Cell Line Development, Biogen