Cambridge Healthtech Institute’s 4th Annual

Advances in Purification & Recovery

New Materials, Technologies and Processes for Novel Products

August 15-16, 2018

New and emerging molecules coming down the pipeline bring a new set of challenges to the downstream team. Now, not only do they have to meet higher upstream titers, they have to come up with strategies to purify these novel and unconventional formats. Biopharm companies are thus increasingly looking to process intensification methods including high throughput, automation, mechanistic modeling and integrated manufacturing strategies to meet these challenges while improving productivity and reducing cost.

At CHI’s 4th Annual Advances in Purification & Recovery conference, scientist will share their pursuit of new materials, technologies and approaches to enhance productivity and reduce bottlenecks, and highlight strategies and best practices in downstream purification of novel, non-platform products from bispecific antibodies, cell and gene therapies, to viral vaccines and microbial-expressed proteins.

Preliminary Agenda


KEYNOTE PRESENTATION: ProTIA: Challenges with Isolation and Purification of a Novel, XTENylated Bispecific T Cell Engager Therapeutic

Ulrich Ernst, COO/Senior Vice President, Technical Operations, AMunix Operating, Inc.

Developing an Integrated Manufacturing Platform for Antibodies and ADCs

Felix Oehme, PhD, Head, Biological Development, Bayer AG

Overcoming Challenges for Developing a Platform Process for Early Phase ADC Manufacturing under Tight Timelines

Chi Zhang, PhD, Scientist, Process Development, Ambrx

A Practical Self-Cleaving Tag Platform for Initial Capture of Complex Glycoproteins

David W. Wood, PhD, Professor, Chemical and Biomolecular Engineering, Ohio State University

Modular Buffer Mixing for Automated Membrane Protein Purification Using Akta Avant

Jonas Lee, PhD, Scientist, Protein Technologies, Amgen

Challenges in Purifying Influenza Virus-Like Particles

Cristina Peixoto, Head Downstream Process, Animal Cell Technology, iBET Instituto de Biologia Experimental Tecnologica


Enhanced Affinity Capacity via Novel Utilization of Hydrophobic Interactions

Keith Selvitelli, Senior Associate Scientist, Process Biochemistry, Biogen

Synthetic Peptide Ligands for Improved Clearance of CHO Host Cell Proteins

Stefano Menegatti, PhD, Professor, Chemical and Biomolecular Engineering, North Carolina State University

An Universal Platform for Protein Purification (UPPP) by Liquid Chromatography

Xindu Geng, PhD, Professor, Separation Science and Technology, Northwest University, Suzhou, China

New Depletion Technology for Mid-Stream Purification Operation

Fabien Rousset, PhD, Head, Bioseparations Business Unit, DAICEL/Chiral Technologies Europe


Advanced Modeling of Process Chromatography Combining CFD with Mass Transfer Models

Alois Jungbauer, PhD, Professor, Biotechnology, University of Natural Resources and Life Sciences, Vienna and Austrian Centre of Industrial Biotechnology

High Concentration Ultrafiltration Challenges in Manufacturing Platform

Mahsa Hadidi, PhD, Process Engineer III, Global MSAT Process Sciences, Sanofi Genzyme

Feedback Control System for mAb Downstream Purification

Lizy Kaiyan Tang, MSc, Senior Scientist, MMD, BVA, PAT, Merck

Implementation of Design Space Strategy to Control Product Quality during Large Scale Purifiation of Therapeutic Proteins

Lonela Iliescu, MSc, Scientist I, Technical Development, Biogen

For more details on the conference, please contact:

Mimi Langley
Senior Conference Director
Cambridge Healthtech Institute
Phone: 781-972-5439

For partnering and sponsorship information, please contact:

Companies A-K

Sherry Johnson
Senior Business Development Manager
Cambridge Healthtech Institute
Phone: 781-972-1359

Companies L-Z

Carolyn Benton
Business Development Manager
Cambridge Healthtech Institute
Phone: 781-972-5412


Premier Sponsors:

Millipore Sigma

Unchained Labs