Cambridge Healthtech Institute’s 12th Annual
Gene Therapy Manufacturing
Optimizing Process Development and Manufacturing for Late-Stage Success
June 16-17, 2027
Cambridge Healthtech Institute’s 12th Annual Gene Therapy Manufacturing conference explores the latest process development and manufacturing strategies driving cost-effective gene therapy production across clinical, late-stage, and commercial manufacturing. Topics include innovations in upstream and downstream processing, producer cell lines and intensified transfection, using optimized media, plasmid ratios and titer boosters, through to continuous chromatography, affinity resins, and full capsid enrichment. Be late-stage ready with insights on tech transfer, inspection readiness, manufacturing sciences for PPQ, continued process verification, deviation management, device compatibility, characterization and comparability. Additional topics include AAV, lentiviral and LNP process control, scaling AAV to 2,000 L and beyond, and cutting COGS through AI-enabled development and automation.
Coverage will include, but is not limited to:
- Innovations in gene therapy upstream and downstream process development (viral and non-viral)
- Late-stage considerations and commercial readiness of gene therapy programs and supply chain challenges, including PPQ
- Device compatibility studies and the role of CMC in the discussion
- Applying best practice in late-stage development, from robust characterization and comparability to commercial readiness
- Lifting productivity through cell line development, from triple transfection to producer cell lines
- Intensifying upstream with optimized media, culture conditions, plasmid ratios, transfection reagents and small molecule titer boosters
- Advancing downstream purification with continuous chromatography, affinity resin selection, and empty and full capsid separation
- Scaling AAV and engineered capsid production to 2,000 L and beyond while reducing cost-of-goods through intensification, AI-enabled development, and automation
The deadline for priority consideration is November 20, 2026.
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation:
- To submit a podium presentation, please click here.
- To become a sponsor, click here.
- To present a poster, click here.
- To sign up to attend, click here.