Cambridge Healthtech Institute’s 10th Annual

Optimizing Cell Line Development

Enhancing Expression

August 16-17, 2018


Cell Line Development has reached a new plateau influenced by genomic research and insights, along with emerging technologies that are pushing cell engineering into an uncharted future. The “Optimizing Cell Line Development” conference brings together cell line development experts who are forging this new era. They will share how to best optimize codons, construct vectors, and how to select and engineer clones and host systems, while maintaining stability and consistency. The conference will also focus on genomic research for CHO and other systems, as well as glycoengineering, systems biology, assays, and pathway delineation. In addition, challenges for introducing new technologies will be discussed, along with an overview of industrial trends and regulatory perspectives.


Preliminary Agenda


NEXT-GEN STRATEGIES FOR DEVELOPING CELL LINES

KEYNOTE PRESENTATION:

Product Quality Control Strategies during Cell Line Development

Zhimei Du, PhD, Director, Cell Line Development, Merck & Co., Inc.


FEATURED PRESENTATION:

Robust and Flexible Approaches towards High-Quality Cell Lines

Volker Sandig, MBF, CSO, ProBioGen AG

Programmed Gene Regulatory Networks for Cell Line Engineering

Ron Weiss, PhD, Professor, Biological Engineering Department, Massachusetts Institute of Technology (MIT)


CHO-BASED CELL LINE DEVELOPMENT

Evaluating CRISPR-Cpf1 as a Genome Editing Technology in Chinese Hamster Ovary (CHO) Cells

Zhuo Cheng, PhD, Research Scientist, Molecular and Cell Biology, Bioprocess R&D, Eli Lilly and Company

Unlocking the Mysteries of CHO Cells Using Transcriptomic Analysis

Clare Trippett, PhD, Technology and Innovation Officer, Biologics, Centre for Process Innovation

Optimization of a Stable CHO-K1-Based Cell Line for FAP-DR5 2+2 CrossMab Antibody to Increase Product Quality and Yield

Stefan Seeber PhD, Principal Scientist, Molecule & Cell Line Development, Roche Innovation Center Penzberg


OVERCOMING CELL LINE CHALLENGES

Cell Line Development for Expression of Bispecific and Trispecific Molecules

Valentina C. Ciccarone, PhD, Principal Scientist, Cell Line Development, Macrogenics, Inc

Optimization of Amplicon Sequencing to Enable Sequence Variant Screening for a Non-Conventional Cell Line Development Program

Yizhou Zhou, PhD, Scientist II, Cell Culture Development, Biogen


RNA TECHNOLOGY

Utilizing RNA Epigenetic Modifications to Enhance Transgene Expression

Niall Barron, PhD, Professor, Biochemical Engineering, National Institute for Bioprocessing Research and Training (NIBRT), University College Dublin (UCB)

Improving Protein Expression by Implementing Noncoding RNA

Joseph Shiloach, PhD, Head, Biotechnology Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH)

A Novel Approach to Cell Line Selection Using RNA

Ted Eveleth, CEO, HocusLocus, Inc.


ADVANCING CELL LINE DEVELOPMENT

Leaping-In to Cell Line Development: An Evaluation of ATUM’s Leap-In Transposase System

Neal Schilling, PhD, Senior Scientist, Process Sciences, CHO Cell Line Development, AbbVie Bioresearch Center

Higher Throughput Cell Line Development Using the VIPS (Verified in situ Plate Seeding)

Thomas Kelly, Scientist, Cell & Developability Sciences, Janssen R&D

Automate Research Cell Line Generation with I-Cell Technology

Leyu Wang, PhD, Senior Scientist II, Global Protein Sciences, Biologics, AbbVie Bioresearch Center




For more details on the conference, please contact:
Mary Ruberry
Senior Conference Director
Cambridge Healthtech Institute
Phone: 781-972-5421
Email: mruberry@healthtech.com


For partnering and sponsorship information, please contact:

Companies A-K

Sherry Johnson
Senior Business Development Manager
Cambridge Healthtech Institute
Phone: 781-972-1359
Email: sjohnson@healthtech.com

Companies L-Z

Carolyn Benton
Business Development Manager
Cambridge Healthtech Institute
Phone: 781-972-5412
Email: cbenton@healthtech.com


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Premier Sponsors:

Millipore Sigma
Unchained Labs