Cambridge Healthtech Institute’s 9th Annual
Optimizing Cell Line Development
Enhancing Expression
Part of CHI's Ninth Annual The Bioprocessing Summit

August 24-25, 2017 | Westin Copley Place | Boston, MA


The Optimizing Cell Line Development conference brings together cell line development experts who share real-world strategies for quickly achieving cell lines that meet bottom-line goals. Their practical and detailed insights illustrate how to best optimize codons, construct vectors, and how to select and engineer clones and host systems, while maintaining stability and consistency. Gaining a greater understanding of cells through sequencing and the omics sciences will also be addressed, including the CHO genome research, glycoengineering, systems biology, assays, and pathway delineation. In addition, challenges for introducing new technologies will be discussed, along with an overview of industrial trends and regulatory perspectives.

Preliminary Agenda


CELL LINE DEVELOPMENT FOR INDUSTRIAL USE


KEYNOTE PRESENTATION:
Efficient Cell Line Development for Production and Regulatory Success

Pamela Hawley-Nelson, Ph.D., Associate Director, R&D, and Head, Cell Biology in Process Cell Culture, MedImmune, Inc.


Transient Protein Production: Harmonizing the Process from Construct Generation through Protein Characterization

Richard Altman, MS, Scientist, Protein Technologies, Amgen, Inc.

Optimizing CHO Cell Culture Process through Mechanistic Understanding of Cysteine Capping Modifications for Improving Site-Specific ADCs 

Xiaotian Zhong, Ph.D., Senior Principal Scientist/Lab Head, Biomedicine Design, Pfizer Worldwide R&D


GLYCOSYLATION

Optimization and Control of Human Glycosylation during Biotherapeutic Development

Rainer Stahn, Ph.D., Director, Process Development, Glycotope GmbH

Glycoengineering in Mammalian Cells

Claus Kristensen, Ph.D., Associate Professor, Cellular and Molecular Medicine, Copenhagen Center for Glycomics, University of Copenhagen

Investigating Alterations in the CHO N-Glycome Following Exposure to Leachables from Single-Use Bioreactors

Jonathan Bones, Ph.D., Principal Investigator, Characterization and Comparability Laboratory, National Institute for Bioprocessing Research and Training (NIBRT)

Strategies for the Control of Glycosylation during the Production of a Recombinant Protein

Michael Butler, Ph.D., Distinguished Professor Emeritus, University of Manitoba, and CSO, Cell Technology, National Institute of Bioprocessing Research & Training (NIBRT)


EMPLOYING EMERGING TOOLS

Using CRISPR/Cas9 for High-Throughput Variant Generation in Saccharomyces cerevisiae

Christian Schrøder Kaas, Ph.D., Postdoctoral Researcher, Yeast Technology, Novo Nordisk A/S


CLONE SELECTION AND OPTIMIZATION

FACS-Based Clone Selection and Host Cell Engineering to Improve the Production and Quality of Recombinant Proteins in CHO Cells

Elizabeth Scheideman, Ph.D., Director, Cell Line Development, Vaccine Production Program, Vaccine Research Center, National Institutes of Health (NIH)

BESTcell: Fast Cell Line Development for CHO Clones with High-Yield Protein Production Using Euchromatin-Containing BAC Expression Vectors

Anton Bauer, Ph.D., COO, The Antibody Lab GmbH




For more details on the conference, please contact:
Mary Ruberry
Senior Conference Director
Phone: 781-972-5421
Email: mruberry@healthtech.com

For media partnership opportunities, please contact:
Kaushik Chaudhuri
Director of Product Marketing
Phone: 781-972-5419
Email: kchaudhuri@healthtech.com

For exhibit & sponsorship opportunities, please contact:

Companies A-K
Sherry Johnson
Business Development Manager
Phone: 781-972-1359
Email: sjohnson@cambridgeinnovationinstitute.com

Companies L-Z
Carolyn Benton
Business Development Manager
Phone: 781-972-5412
Email: cbenton@healthtech.com

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Event at a Glance
Event at a Glance


Celebrating 25 Years


 

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